In order to facilitate the pipeline transportation of Liaohe heavy oil, the water separation rate and viscosity reduction rate are two important research parameters. Influence mechanism of the types and mass fractions of surfactants, organic alkalis and the Ca2+ on stability and rheology of Liaohe heavy oil emulsion were investigated through the viscosity reduction experiments of heavy oil emulsification . The results of the study indicate that different surfactants have diverse molecular structures, which would induce different properties at oil?water interface, leading to greater differences in the rheology and stability of the emulsion. Amphoteric surfactant LAO?30 was used to configure the Liaohe heavy oil O/W emulsion, its water separation rate and viscosity reduction rate decrease with the increasing of the mass fraction of LAO?30. The surfactant LAO?30 mixed with organic alkali, such as TEA, ETA, and TEOA, shows synergistic effect of the two components and improves the stability of the emulsion. Considering the viscosity reduction rate, water separation rate, and environmental protection of the emulsion, the optimized quality fraction of 0.20% ETA and 0.75% LAO?30 are selected. The emulsions obtained by emulsificating have a great improvement in the resistance to hard water. When the mass fraction of CaCl2 reaches 0.20%, the water separation rate within 6 hours of the emulsion is 24.4%.